To maximize social reach, you have to follow everyone with whom you share a vision - in my case, teachers - then it's up to you to filter your feed so that you read the tweets you feel you need to read.)
The Dalai Lama tweets about twice per week. Meditate on that.
I want to love twitter, but it's difficult right now. Everyone has some interesting things to say about their passion (education in my case), and I want to hear everything they say. But many of these people tweet dozens of times per day.
I have about 15 minutes per day that I can budget for Twitter. I think that's about par for the course for many working adults. I want to learn new ideas, and what better platform than Twitter? But 15 minutes is about enough time to scan maybe 200 tweets, click on four or five items that are interesting, and explore these items. So at this rate, I can follow about 150 people who tweet once or twice per day.
Twitter is a platform for sharing awesome ideas with the whole world. Does anyone really have more that one or two awesome things to share with the world per day? I don't think so. I wish most people would be excruciatingly judicious about what they tweet. We are tweeting to the whole world; let's show some restraint.
Of course this "1 or 2 tweet per person" ideal has some notable exceptions. When you are attending a conference, or if you are in weekly tweetup like #edchat, then you are effectively in a chat room and you have a lot to say. And of course if you are a young person who is still in school, then by golly you tweet all day about Aston Kutcher's breakfast or anything else that you fancy.
I'm having a very hard time finding interesting people who are judicious about tweeting. I subscribe to less than 30 people. I'd like to find more, but it is not so easy. It seems like people are either totally absent from twitter, or they are twitter junkies and tweet a jillion times per day; there does not seem to be much middle ground.